Network-assisted analysis to prioritize GWAS results: principles, methods and perspectives

Network analysis of GWAS data.

Genome-wide association studies (GWAS) identify genetic variants that distinguish a control population from a population with a specific trait. Two challenges in GWAS are: (1) identification of the causal variant within a longer haplotype that is associated with the trait; (2) identification of causal variants for polygenic traits that are caused by variants in multiple genes within a pathway. ...

Principles of GWAS

Network-Based Analysis of eQTL Data to Prioritize Driver Mutations

In clonal systems, interpreting driver genes in terms of molecular networks helps understanding how these drivers elicit an adaptive phenotype. Obtaining such a network-based understanding depends on the correct identification of driver genes. In clonal systems, independent evolved lines can acquire a similar adaptive phenotype by affecting the same molecular pathways, a phenomenon referred to ...

A Network-Based Approach to Prioritize Results from Genome-Wide Association Studies

Genome-wide association studies (GWAS) are a valuable approach to understanding the genetic basis of complex traits. One of the challenges of GWAS is the translation of genetic association results into biological hypotheses suitable for further investigation in the laboratory. To address this challenge, we introduce Network Interface Miner for Multigenic Interactions (NIMMI), a network-based me...

specialized methods to teach spelling: comparing three methods

چکیده: بررسی ادبیات مربوطه در کشور در زمینه یادگیری زبان انگلیسی نشان می‎دهد که علی‎رغم اهمیت املا در فرآیند یادگیری به طور عام و یادگیری زبان انگلیسی به طور خاص، این مولفه از جایگاهی متناسب با اهمیت آن برخوردار نیست و عمدتاً نادیده گرفته شده است. تحقیقات گسترده‎ای در خارج از کشور در مورد ماهیت این مولفه صورت گرفته است، در حالی که به جرأت می‎توان گفت در داخل کشور گامی در مورد درک ماهیت آن و فرآی...